Recombinant CD23/FCER2 Monoclonal Antibody (AN300547P)
For research use only.
| Verified Samples |
Verified Samples in IF: Mouse splenocytes Verified Samples in FCM: BABL/c splenocytes |
| Dilution | ICC/IF 1:20-1:100, FCM 1:25-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Mouse |
| Applications | FCM, ICC/IF |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse CD23/FCER2 Protein |
| Abbre | FCER2 |
| Synonyms | Fce, FCER, CD23, Fce2, Fc-epsilon-RII, Ly-42, Lymphocyte IgE receptor, Fcer2a, Fcer2, Fc&, epsilon-RII-I, Ly-42, BLAST-2, CD23A, CLEC4J, Fc epsilon RII, IGEBF |
| Swissprot | |
| Cellular Localization | Cell membrane, Secreted |
| Concentration | 1 mg/mL |
| Buffer | 0.2 μm filtered solution in PBS |
| Purification Method | Protein A |
| Clone No. | B477 |
| Conjugation | Unconjugated |
| Storage | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Shipping | Ice bag |
| background | CD23, also known as FcεRII, is a trimeric type II transmembrane glycoprotein member of the calcium-dependent (C-type) lectin family. CD23 is expressed in B and T lymphocytes, monocytes, polymorphonuclear leukocytes, follicular dendritic cells, intestinal epithelial cells, and bone marrow stromal cells. CD23 was first identified as a low-affinity receptor for IgE and the engagement of membrane bound CD23 leads to suppressed IgE production by B lymphocytes. CD23 can be cleaved to form a soluble protein which can drive cytokine release in monocytic cells, nitric oxide (NO) production, and the synthesis of cyclic adenosine 3′5′-monophosphate (cAMP). Soluble CD23 signals through integrins, activating MAPK and NF-κB pathways. CD23 is a useful marker in the prognosis of neoplastic disease, is elevated in a variety of autoimmune and inflammatory conditions, and is being investigated as a therapeutic target for IgE-mediated allergy, arthritis, and B cell chronic lymphocytic leukemia (CLL). |
Other Clones
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Other Formats
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Unconjugated
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