Recombinant Dopamine beta Hydroxylase Monoclonal Antibody (AN301975L)
For research use only.
| Verified Samples | Verified Samples in IHC: Human adrenal gland, Human kidney (negative tissue), Human testis (negative tissue) |
| Dilution | IHC 1:50-1:100 |
| Isotype | IgG, κ |
| Host | Rabbit |
| Reactivity | Human, |
| Applications | IHC |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Peptide. This information is proprietary to PTMab. |
| Abbre | Dopamine beta Hydroxylase |
| Synonyms | OTTHUMP, DBH, DBM, Dopamine beta hydroxylase, Dopamine beta monooxygenase, Dopamine beta-hydroxylase (dopamine beta-monooxygenase), Dopamine beta-monooxygenase, DOPO, OTTHUMP00000022501, Soluble dopamine beta-hydroxylase, dopamine beta-hydroxylase, Dopamine β-hydroxylase |
| Swissprot | |
| Cellular Localization | Cytoplasmic vesicle, Secreted |
| Concentration | 1 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A purified |
| Research Areas | Neuroscience, Cancer, Metabolism |
| Clone No. | A691 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | Dopamine β-Hydroxylase (DBH) is an enzyme of the copper type II ascorbate-dependent mono-oxygenase family. This enzyme forms homotetramers composed of two noncovalently bound disulfide-linked dimers and is found as both membrane-associated and soluble forms. The soluble form is present in the lumen of secretory granules and is released from cells by exocytosis. DBH converts dopamine to noradrenaline. Deficiency in this enzyme causes a rare disease characterized by a complete absence of noradrenaline and adrenaline in plasma together with increased plasma dopamine levels. Orthostatic hypotension, the main symptom of DBH deficiency, can be alleviated by administration of dihydroxyphenylserine, a synthetic precursor of noradrenaline. |
Other Clones
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Unconjugated
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