Recombinant DPP4/CD26 Monoclonal Antibody (AN301964L)

Name: Recombinant DPP4/CD26 Monoclonal Antibody
Brand: Elabscience
SKU: AN301964L
Price: 249.0 USD
Availability: InStock

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Recombinant DPP4/CD26 Monoclonal Antibody - 1

All	Size	Price	Qty
	100μL	$ 380.00	- +
	50μL	$ 249.00	- +

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Verified Samples	Verified Samples in WB: U87-MG, PC-3, Human liver, Mouse thymus, Rat thymus Verified Samples in IHC: Human kidney, Mouse liver, Human thyroid(Negative tissue), Mouse testis(Negative tissue)
Dilution	WB 1:500-1:1000, IHC 1:200-1:500
Isotype	IgG, κ
Host	Rabbit
Reactivity	Human, Rat, Mouse
Applications	WB, IHC
Clonality	Monoclonal;Recombinant
Immunogen	Recombinant human DPP4/CD26 fragment
Abbre	DPP4/CD26
Synonyms	DPP, dipeptidylpeptidase, dipeptidyl-peptidase, dipeptidyl peptidase, T-cell activation antigen CD, adenosine deaminase complexing protein, DPP4, ADABP, ADCP2, CD26, DPPIV, TP103, Dipeptidyl peptidase IV, ADCP-2, dipeptidyl-peptidase 4, dipeptidyl peptidase 4, DPP IV, dipeptidylpeptidase 4, T-cell activation antigen CD26, adenosine deaminase complexing protein 2, dipeptidylpeptidase IV, Dipeptidyl peptidase IV (DPP IV), ADABP Protein, ADCP2 Protein, CD26 Protein, DPPIV Protein, Human, TP103 Protein
Swissprot	P27487
Calculated MW	110 kDa
Observed MW	110 kDa Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include: 1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein. 2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes. 3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1. 4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids). 5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers. If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane.
Cellular Localization	Secreted, Membrane
Concentration	1 mg/mL
Buffer	PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Purification Method	Protein A purified
Research Areas	Immunology, Cell Biology, Stem Cells, Cancer, Metabolism
Clone No.	A680
Conjugation	Unconjugated
Storage	Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping	Ice bag
background	DPP4/CD26 is a type II transmembrane glycoprotein expressed ubiquitously in most tissues and different cell types. The protein has a short cytoplasmic domain, transmembrane domain, a flexible stalk fragment and extracellular fragment. Both the catalytic peptide hydrolase domain and the beta-propeller ligand binding domain are located in the extracellular fragment. DPP4/CD26 is a multifunctional protein that exists in both a membrane bound form as well as an extracellular soluble form. As a peptidase, it removes N-terminal dipeptides sequentially from proteins with a proline or alanine as the penultimate P1 amino acid. DPP4/CD26 has been shown to cleave a wide range of substrates including GLP-1, BNP, etc. In addition to its peptidase activity, DPP4/CD26 interacts with multiple important cell surface ligands, such as adenosine deaminase, fibronectin, and IGF2 receptor to influence processes like T cell activation, cell migration and proliferation.