Recombinant Human CRTAM Protein(His Tag) (PDMH100222)
For research use only.
| Synonyms | CD355, Class I MHC restricted T cell associated molecule, Class-I MHC-restricted T-cell-associated molecule, CRTAM, CRTAM, Cytotoxic and regulatory T cell molecule, Cytotoxic and regulatory T-cell molecule |
| Species | Human |
| Expression Host | Mammalian |
| Sequence | Ser18-Gly287 |
| Accession | O95727 |
| Calculated Molecular Weight | 29.5 kDa |
| Observed Molecular Weight | 55-65 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Form | Lyophilized powder |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A, MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains. Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. |
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