Recombinant Human F9 Protein(His Tag) (PDMH100254)
For research use only.
| Synonyms | Christmas Disease, Christmas factor, Coagulant factor IX, Coagulation factor 9, Coagulation factor IX, Coagulation factor IXa heavy chain, F9, FA9, Factor 9, Factor IX Deficiency, FactorIX, FIX, Haemophilia B, HEMB, MGC129641, MGC129642, P19, Plasma Thromboplastic Component, Plasma thromboplastin component, PTC |
| Species | Human |
| Expression Host | stable cell line |
| Sequence | Met1-Thr461 |
| Accession | P00740 |
| Calculated Molecular Weight | 50.6 kDa |
| Observed Molecular Weight | 60-80 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with an Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. |
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