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Recombinant Human FBPase 1/FBP1 Protein (E. coli, His Tag) (PKSH033276)

All Size Price Qty
50μg $ 128.00
10μg $ 58.00
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For research use only.

Synonyms 6-Bisphosphatase 1, 6-Bisphosphate 1-Phosphohydrolase 1, D-Fructose-1, FBP, FBP1, FBPase 1, Fructose-1
Species Human
Expression Host E.coli
Sequence Ala2-Gln338
Accession P09467
Calculated Molecular Weight 37.9 kDa
Observed Molecular Weight 38 kDa
Tag C-His
Bio-activity Not validated for activity
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 1mM EDTA, 20% Glycerol, pH 8.0.
Reconstitution Not Applicable
Background Fructose-1;6-Bisphosphatase 1 (FBPase 1) is a member of the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory protein; which catalyzes the hydrolysis of fructose 1;6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBPase 1 can assume an active R-state; or an inactive T-state. FBPase 1 deficiency is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis in newborn infants or young children. FBPase 1 coupled with phosphofructokinase (PFK) is involved in the metabolism of pancreatic islet cells.
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