Recombinant Human IL-6RA (C-Fc) (PKSH034017)
For research use only.
| Synonyms | Membrane glycoprotein, CD126, gp80, IL6Q, IL-6R, IL-6R 1, IL-6R subunit alpha, IL-6R-1, IL6RA, IL-6RA, IL-6R-Alpha, IL6RQ, Interleukin-6 receptor subunit alpha, Membrane glycoprotein 80, IL6R, IL-6R&, alpha, alpha, CD 126, CD126 antigen, IL 6R, IL 6R 1, IL 6R alpha, IL-6 receptor alpha chain, IL-6 receptor subunit alpha, IL-6R 1 Membrane glycoprotein 80 (gp80), Interleukin 6 receptor, MGC30256 |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Leu20-Pro365 |
| Accession | P08887 |
| Calculated Molecular Weight | 65.4 kDa |
| Observed Molecular Weight | 85-100 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. |
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