Recombinant Human NGAL/Lipocalin-2 Protein (His Tag, E.coli) (PKSH032807)
For research use only.
| Synonyms | 25 kDa alpha-2-microglobulin-related subunit of MMP-9, HNL, Lipocalin-2, NGAL, Neutrophil gelatinase-associated lipocalin, Oncogene 24p3, Siderocalin LCN2, p25 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Gln21-Gly198 |
| Accession | P80188 |
| Calculated Molecular Weight | 21.8 kDa |
| Observed Molecular Weight | 20-23 kDa |
| Tag | C-His |
| Bio-activity | Not validated for activity |
| Purity | > 90 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH 7.4. |
| Reconstitution | Not Applicable |
| Background | Neutrophil gelatinase-associated lipocalin(LCN2) is a secreted protein and belongs to the calycin superfamily. This protein is released from injured tubular cells after various damaging stimuli; is already known by nephrologists as one of the most promising biomarkers of incoming Acute Kidney Injury (AKI). Recent evidence also suggests its role as a biomarker in a variety of other renal and non-renal conditions. Moreover; recent studies seem to suggest a potential involvement of this factor also in the genesis and progression of chronic kidney diseases. NGAL is the first known mammalian protein which specifically binds organic molecules called siderophores; which are high-affinity iron chelators. NGAL; first known as an antibacterial factor of natural immunity; and an acute phase protein; is currently one of the most interesting and enigmatic proteins involved in the process of tumor development. acting as an intracellular iron carrier and protecting MMP9 from proteolytic degradation; NGAL has a clear pro-tumoral effect; as has already been observed in different tumors (e.g. breast; stomach; oesophagus; brain) in humans. In thyroid carcinomas; NGAL is strongly induced by NF-kB; an important factor involved both in tumor growth and in the link between chronic inflammation and neoplastic development. Thus; Lipocalin-2 (LCN2/NGAL) has been implicated in a variety of processes including cell differentiation; proliferation; survival and morphogenesis. |
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