Recombinant KIR3DL1 Monoclonal Antibody (AN301890L)
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For research use only.
| Verified Samples |
Verified Samples in WB: K562, Raji, Jurkat Verified Samples in IHC: Human prostate hyperplasia, Mouse cerebrum, Rat cerebrum |
| Dilution | WB 1:500-1:2000, IHC 1:50-1:1000 |
| Isotype | IgG, κ |
| Host | Rabbit |
| Reactivity | Human, Rat, Mouse |
| Applications | WB, IHC |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant human KIR3DL1 fragment |
| Abbre | KIR3DL1 |
| Synonyms | NKB, NKAT, KIR3DL, CD158E, NKAT3, NKB1, KIR3DL1, NKB1, NKB1B, p70, AMB11, CD158 antigen-like family member E, CD158e antigen, CD158E1, CD158E1/2, CD158E2, CL11, CL2, HLA-BW4-specific inhibitory NK cell receptor, KI3L1, killer cell immunoglobulin like receptor, Killer cell immunoglobulin like receptor three domains, Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1, Killer cell immunoglobulin-like receptor 3DL1, KIR, KIR antigen 3DL1, KIR G1, KIR3DS1, Kirl1, Kirl2, Krl1, MGC119726, MGC119728, MGC126589, MGC126591, MHC class I NK cell receptor, Natural killer associated transcript 3, Natural killer cell inhibitory receptor, Natural killer-associated transcript 3, NK receptor, NK-associated transcript 10, NK-associated transcript 3, NK-associated transcript 3delIg1, NKAT10, NKAT-3, NKB1B, p70 killer cell inhibitory receptor, p70 natural killer cell receptor clones CL 2/CL 11, p70 natural killer cell receptor clones CL-2/CL-11, p70 NK receptor CL-2/CL-11, short cytoplasmic tail |
| Swissprot | |
| Calculated MW | 49 kDa |
| Observed MW |
38 kDa
The actual band is not consistent with the expectation.
Western blotting is a method for detecting a certain protein in a complex sample based on the specific binding of antigen and antibody. Different proteins can be divided into bands based on different mobility rates. The mobility is affected by many factors, which may cause the observed band size to be inconsistent with the expected size. The common factors include: 1. Post-translational modifications: For example, modifications such as glycosylation, phosphorylation, methylation, and acetylation will increase the molecular weight of the protein. 2. Splicing variants: Different expression patterns of various mRNA splicing bodies may produce proteins of different sizes. 3. Post-translational cleavage: Many proteins are first synthesized into precursor proteins and then cleaved to form active forms, such as COL1A1. 4. Relative charge: the composition of amino acids (the proportion of charged amino acids and uncharged amino acids). 5. Formation of multimers: For example, in protein dimer, strong interactions between proteins can cause the bands to be larger. However, the use of reducing conditions can usually avoid the formation of multimers. If a protein in a sample has different modified forms at the same time, multiple bands may be detected on the membrane. |
| Cellular Localization | Cytoplasm, Membrane |
| Concentration | 1 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A purified |
| Research Areas | Immunology |
| Clone No. | A606 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR3DL1 is a receptor on natural killer (NK) cells for HLA Bw4 allele. It inhibits the activity of NK cells thus preventing cell lysis. KIR3DL1 and KIR3DS1 are highly homologous. This antibody is raised against human KIR3DL1and has a molecular weight of 49 kDa. |
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Unconjugated
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