Recombinant Mouse TSLP Protein(Fc Tag) (PDMM100130)
For research use only.
| Synonyms | Thymic stroma-derived lymphopoietin, Thymic stromal lymphopoietin, Tslp |
| Species | Mouse |
| Expression Host | Mammalian |
| Sequence | Met1-Glu140 |
| Accession | Q9JIE6 |
| Calculated Molecular Weight | 40.2 kDa |
| Observed Molecular Weight | 45 kDa |
| Tag | C-Fc |
| Bio-activity | Not validated for activity |
| Purity | > 90% as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Thymic Stromal Lymphopoietin (TSLP) was originally identified as an activity from the conditioned medium of a Mouse thymic stromal cell line that promoted the development of B cells. The activities of Mouse TSLP overlap with , but are distinct from , those of Mouse IL-7. Both Mouse TSLP and IL-7 can co-stimulate growth of thymocytes and mature T cells , and support B lymphopoiesis in long-term cultures of fetal liver cells and bone-marrow cells. Whereas Mouse IL-7 facilitates the development of B220+/IgM-pre-B cells , Mouse TSLP promotes the development B220+/IgM+ B cells. Human TSLP was reported to preferentially stimulate myeloid cells, inducing the release of T cell-attracting chemokines from monocytes and enhancing the maturation of CD11c+ dendritic cells. Mouse TSLP cDNA encodes a 140 amino acid (aa) residue precursor protein with a 19 aa signal sequence. Within the mature region , there are three potential N-glycosylation sites and 7 cysteine residues. Mouse TSLP shares approximately 43% aa sequence identity with Human TSLP. The gene for Mouse TSLP has been localized to chromosome 18. By Northern and RT-PCR analysis , Mouse TSLP expression has been detected in spleen , thymus , kidney , lung and bone marrow. TSLP is proposed to signal through a heterodimeric receptor complex that consists of IL-7 R alpha and the TSLP R , a new member of the hemopoietin receptor family most closely related to R gamma c. |
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