Recombinant MYH9 Monoclonal Antibody (AN301290L)
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For research use only.
| Verified Samples | Verified Samples in IHC: Human kidney |
| Dilution | IHC 1:200-1:1000, WB 1:2000-1:10000, IF 1:200-1:1000, ELISA 1:5000-1:20000, IP 1:50-1:200, |
| Isotype | IgG,κ |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, IP, ELISA |
| Clonality | Monoclonal;Recombinant |
| Immunogen | Recombinant Human MYH9 protein |
| Abbre | MYH9 |
| Synonyms | MYH, DFNA, BDPLT, myosin, MYH9, BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA, myosin-9, heavy chain 9, myosin heavy chain 9, non-muscle, MYH9 |
| Swissprot | |
| Cellular Localization | Cytoplasm, cytoskeleton, Cytoplasm, cell cortex, Cytoplasmic vesicle, secretory vesicle, Cortical granule, Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (PubMed:20052411). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (PubMed:27331610). |
| Concentration | 0.2 mg/mL |
| Buffer | PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant. |
| Purification Method | Protein A |
| Research Areas | Signal Transduction |
| Clone No. | B1053 |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | Ice bag |
| background | This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. |
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