TRPC4AP Polyclonal Antibody (E-AB-17161)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Human thyroid cancer |
| Dilution | IHC 1:30-150 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Fusion protein of human TRPC4AP |
| Abbre | TRPC4AP |
| Synonyms | TRPC4AP, C20orf188, Chromosome 20 open reading frame 188, Protein TAP1, Protein TRUSS, Short transient receptor potential channel 4 associated protein, Short transient receptor potential channel 4-associated protein, TAP1 protein, TNF receptor ubiquitous scaffol |
| Swissprot | |
| Cellular Localization | Plasma Membrane, Other locations: Cul4A-RING E3 ubiquitin ligase complex. |
| Concentration | 0.9 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Epigenetics and Nuclear Signaling, Signal transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | TRPC4AP (transient receptor potential cation channel, subfamily C, member 4 associated protein), also known as TRUSS or TRRP4AP, is a 797 amino acid protein that is expressed in a variety of tissues, with highest expression in liver, heart, testis and brain. Thought to function as a scaffolding protein, TRPC4AP interacts with TNF-R1 and may both link TNF-R1 to the IKK signalsome complex, and participate in the activation of NFκB p50, an event that occurs in response to TNF-R1 ligation. TRPC4AP exists as multiple alternatively spliced isoforms that are encoded by a gene whicHuman, Mouseaps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. |
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