Flow Cytometry
What is the difference between Mouse CD90 and CD90.1 and CD90.2?
Source: Elabscience®Published: Mar 04,2024
CD90, also known as Thy1 (thymus cell antigen 1), is a mouse immune cell surface molecule. In mice, there are two main subtypes of CD90: CD90.1 and CD90.2. The difference between the two subtypes is due to allelic differences on the loci. CD90.1 and CD90.2 are expression variants controlled by different gene alleles. For example, in C57BL/6 mice, CD90.1 expression is regulated by the Ly5.2 locus, while CD90.2 is controlled by the Ly5.1 locus. Due to the differences in the loci of CD90.1 and CD90.2, these subtypes can be used for labeling in experiments to distinguish cells of different origin. By introducing the allele of CD90.1 or CD90.2, cells can be genetically labeled to identify, trace and quantitatively analyze cells of specific origin. CD90 can be expressed on hematopoietic stem cells, neurons, all thymic cells, and peripheral T cells. The mouse strains expressing CD90.1 included AKR, BDP, MA/MyJ, etc., and more mouse strains expressing CD90.2 included Balb/c, CBA/J, C3H/He, C57BL/-, DBA, NZB/-, etc.