ACTN1 Monoclonal Antibody

Uniprot : P12814
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
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    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience

      Catalog number:E-AB-22127

      Synonyms:actinin 1 smooth muscle,Actinin alpha 1,actinin,alpha 1,ACTN 1,Actn1,ACTN1,Alpha Actinin 1,Alpha actinin cytoskeletal isoform,Alpha-actinin cytoskeletal isoform,Alpha-actinin-1,BDPLT15,F actin cross linking protein,F-actin cross-linking protein,FLJ40884,FLJ54432,Non muscle alpha actinin 1,Non-muscle alpha-actinin-1

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Mouse

      Reactivity: H,M,R

      Applications: IHC-p

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms actinin 1 smooth muscle,Actinin alpha 1,actinin,alpha 1,ACTN 1,Actn1,ACTN1,Alpha Actinin 1,Alpha actinin cytoskeletal isoform,Alpha-actinin cytoskeletal isoform,Alpha-actinin-1,BDPLT15,F actin cross linking protein,F-actin cross-linking protein,FLJ40884,FLJ54432,Non muscle alpha actinin 1,Non-muscle alpha-actinin-1
      Swissprot P12814
      Source Mouse
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant Protein of a-actinin of ACTN1
      Application IHC-p(Detection kit: E-IR-R217)
      Recommended dilution IHC 1:100-200
      Concentration 1 mg/mL
      Clonality Monoclonal

      Properties

      Cellular localization Cytoplasm>cytoskeleton. Cytoplasm>myofibril>sarcomere>Z line. Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle.
      Clone No. Clone:1D4
      Isotype IgG
      Purification Protein A purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
      Background Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

      Images

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      Immunohistochemistry of paraffin-embedded Human kidney tissue using ACTN1 Monoclonal Antibody at dilution of 1:200.

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