Purified Anti-Human/Mouse IL-5 Antibody[TRFK5], Functional Grade (E-AB-F12050)
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For research use only.
| Alternate Names | B-cell differentiation factor I, IL-5, Interleukin-5, T-cell replacing factor, TRF |
| Clone | |
| Leadtime | Inquire |
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse IL-5 gene |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells);Depletion Reported in the literature;Neut Reported in the literature |
| Background | IL-5 (Interleukin-5) is a secreted cytokine that is expressed as a covalent dimer. It is produced by activated Th2 cells, eosinophils, mast cells, and iNKT cells and promotes eosinophilic and basophilic differentiation and activation. IL-5 signals through a receptor complex containing IL-5 R alpha and the Common beta Chain/CD131 on eosinophils and basophils. Naturally occurring soluble forms of IL-5 R alpha retain the ability to bind IL-5 and limit its bioavailability. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
| Immunogen | Recombinant Mouse IL-5 protein |
| Abbre | IL-5 |
| Swissprot | |
| Host | Rat |
| Reactivity | Human;Mouse |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Rat IgG1, κ |
| Isotype Control | Purified Rat IgG1, κ Isotype Control[HRPN], Functional Grade |
| Applications |
ICFCM;Depletion;Neut
|
| Research Areas | Immunology |
| Cellular Localization |
Secreted
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | None (AF/LE) |
| Storage Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
| Application References | Kelly D Moynihan, et al. Nat Med. 2016 Dec;22(12):1402-1410. Thibault Griser, et al. Immunity. 2015 Jul 21;43(1):187-99. |
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