Current Position:Home>>Antibodies>>Flow Cytometry Antibodies>> AF/LE Purified Anti-Human CD279/PD-1 Antibody[J116] E-AB-F11290
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|Alternate Names||PD-1, Programmed Death-1|
1. Francisco LM, Sage PT, and Sharpe AH. 2010. Immunological Rev. 236:219.
|Clone No.||J116(See Other Available Formats)|
|Isotype||Mouse IgG1, κ|
|Isotype Control||AF/LE Purified Mouse IgG1, κ Isotype Control[MOPC-21] [Product E-AB-F097930]|
|Application||Block,Neut,FCM (See the Application Description)|
|Storage Buffer||0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.|
|Recommended Use||Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.|
|Shipping||Biological ice pack at 4℃|
|Stability & Storage||Keep as concentrated solution.
Store at 2~8°C. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.
|Conjugation||None (Purified antibody-Azide Free/Low endotoxin)|
How to select the appropriate detection channel through the spectrogram?
|Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.|
|Related Protocols||Staining Cell Surface Targets for Flow Cytometry|
|Purified Anti-Human CD279/PD-1 Antibody[J116] E-AB-F1129A||25μg, 100μg||Check More|
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