Purified Anti-Mouse CD106 Antibody[M/K-2.7], Functional Grade (E-AB-F10910)
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For research use only.
| Alternate Names | CD106, INCAM-100, vascular cell adhesion molecule 1, MGC, Vascular cell adhesion protein, Vascular Cell Adhesion Molecule, VCMA, V-CAM, CD106, CD106 Antigen, INCAM 100, INCAM-100, L1CAM, MGC99561, Vascular Cell Adhesion Molecule 1, Vascular cell adhesion protein 1, VCAM 1, V-CAM 1, VCMA1, Vcam-1, Vcam1 |
| Clone | |
| Leadtime | Order now, ship in 3 days |
| Verified Samples | Verified Samples in FCM: C57/BL6 Mouse bone marrow |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells);Neut Reported in the literature |
| Background | VCAM-1 (CD106), a member of the immunoglobulin superfamily, is a cell surface protein expressed by activated endothelial cells and certain leukocytes (such as macrophages). VCAM-1 expression is induced by IL-1 beta, IL-4, TNF-alpha and IFN-gamma. VCAM-1 binds to leukocyte integrins VLA-4 and alpha 4 beta 7. The human and mouse VCAM-1 proteins share approximately 76% amino acid similarity. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
| Immunogen | Recombinant Mouse CD106 protein |
| Abbre | CD106 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Isotype | Rat IgG1, κ |
| Isotype Control | Purified Rat IgG1, κ Isotype Control[HRPN], Functional Grade |
| Applications |
FCM;Neut
|
| Research Areas | Cell Adhesion;Cell Biology;Immunology;Neuroinflammation;Neuroscience;Stem Cells |
| Cellular Localization |
Cell membrane, Secreted
|
| Tissue Specificity |
Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow.
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | None (AF/LE) |
| Storage Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
| Application References | Hanadie Yousef, et al. Nat Med. 2019 Jun;25(6):988-1000. |
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