Purified Anti-Mouse CD119 Antibody[GR-20], Functional Grade (E-AB-F11150)
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For research use only.
| Alternate Names | Interferon gamma receptor 1, IFNGR1, INGR1, IFN-gamma receptor 1, IFN-gamma-R1, CDw119, Interferon gamma receptor alpha-chain, IFN-gamma-R-alpha, CD119, CDw, IFN-gamma-R, IFN gamma receptor, IFN-gamma receptor, immune interferon receptor, INGR, IFN-γ R, CD119, CD119 antigen, CDw119, Ifgr, IFN gamma receptor 1, IFN-gamma receptor 1, IFN-gammaR, IFN-gamma-R1, IFN-gamma-R-alpha, IFN-γ R1, immune interferon receptor 1, INGR1, Interferon gamma receptor 1, Interferon gamma receptor alpha-chain, interferon-gamma receptor alpha chain, Nktar, Ifngr, Ifngr1, IFN&, gamma-R-R, IFN&, gamma-Ra-a, CDw119 |
| Clone | |
| Leadtime | Order now, ship in 3 days |
| Verified Samples | Verified Samples in FCM: C57/BL6 Mouse splenocytes |
| Background | CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-γRα chain. It is a class II cytokine receptor family member that serves as a IFN-γ-binding chain associated with the IFN-γ β chain also known as AF-1. In addition to ligand binding, CDw119 participates in ligand trafficking. CDw119 is expressed on T and B cells, NK cells, fibroblasts, endothelial, and epithelial cells. Binding of IFN-γ induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-γ initiates and regulates a variety of immune responses. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells. |
| Immunogen | Recombinant Mouse CD119 protein |
| Abbre | CD119 |
| Swissprot | |
| Host | Rat |
| Reactivity | Mouse |
| Clonality | Monoclonal |
| Purification Method | >98%, Protein A/G purified |
| Isotype | Rat IgG2a, κ |
| Isotype Control | Purified Rat IgG2a, κ Isotype Control[2A3], Functional Grade |
| Applications |
FCM;Neut
|
| Research Areas | Immunology |
| Cellular Localization |
Cell membrane, Membrane
|
| Tissue Specificity |
Expressed in skeleton of lower jaw and 260 other cell types or tissues.
|
| Concentration |
≥ 1 mg/mL
|
| Conjugation | None (AF/LE) |
| Storage Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Expiration Date | 12 months |
| Shipping | Ice bag |
| Application References | Nadine van Montfoort, et al. Cell. 2018 Dec 13;175(7):1744-1755.e15. |
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