Anti-2019-nCoV S-IgA Neutralizing Antibody

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      Catalog number:E-AB-V1027

      Synonyms:coronavirus s1,coronavirus s2,coronavirus spike,cov spike,ncov RBD,ncov s1,ncov s2,ncov spike,novel coronavirus RBD,novel coronavirus s1,novel coronavirus s2,novel coronavirus spike,RBD,S1,s2,Spike RBD

      Size:
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      • 100μL
      • 200μL
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      Price: $260

      Host: Human

      Applications: Neutralization, ELISA

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      Overview

      Synonyms coronavirus s1,coronavirus s2,coronavirus spike,cov spike,ncov RBD,ncov s1,ncov s2,ncov spike,novel coronavirus RBD,novel coronavirus s1,novel coronavirus s2,novel coronavirus spike,RBD,S1,s2,Spike RBD
      Source Human
      Reactivity SARS-COV2
      Immunogen Recombinant 2019-nCoV S-trimer Protein (His Tag)(PKSR030489)
      Application Neutralization, ELISA
      Recommended dilution ELISA: 1:1,000-1:2,000
      Concentration 1 mg/mL

      Properties

      Clone No. 8A5
      Isotype IgA
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS, pH 7.4
      Background Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

      Images

      Immobilized Recombinant 2019-nCoV S-trimer Protein (C-6His) (Cat#PKSR030489) at 5.0 ug/mL (100 uL/well) can bind Anti-2019-nCoV S-IgA Neutralizing Antibody (8A5), the EC50 is 397 ng/mL.

      Immobilized Recombinant Recombinant 2019-nCoV S Protein RBD-SD1 (C-6His) (Cat#PKSR030477) at 5.0 ug/mL (100 uL/well) can bind Anti-2019-nCoV S-IgA Neutralizing Antibody (8A5), the EC50 is 416.4 ng/mL.

      Anti-2019-nCoV S-IgA Neutralizing Antibody(8A5) can block Human ACE-2 Protein (Avi-His Tag)(Cat#PKSR030493) and 2019-nCoV S-trimer Protein (Cat#PKSR030489) interaction, the IC50 for this effect is 19.8 ng/mL.

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