APC Anti-Human IL-17A Antibody[BL168] (E-AB-F1173E)
![APC Anti-Human IL-17A Antibody[BL168] - 1](http://file.elabscience.com/assets/images/loading.png)
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For research use only.
Conjugation: APC
| Isotype | Mouse IgG1, κ |
| Host | Mouse |
| Reactivity | Human |
| Applications | ICFCM |
| Clonality | Monoclonal |
| Abbre | IL-17A |
| Synonyms | IL17, CTLA-8, CTLA8, IL 17A |
| Swissprot | |
| Cellular Localization | Secreted |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Research Areas | Cell Biology, Immunology, Neuroinflammation, Neuroscience |
| Clone No. | BL168 |
| Conjugation | APC |
| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
| background | IL-17A is the founding member of the IL-17 family, a group of six structurally related pro-inflammatory cytokines. IL-17A, secreted by activated CD4+ Th17 cell subpopulation, elicits multiple biological activities on a variety of cells including: the induction of IL-6, IL-8, G-CSF, and PGE2 production in epithelial, endothelial or fibroblasts; the enhancement of surface expression of ICAM-1 in fibroblasts; activation of NF-κB and costimulation of T cell proliferation. Recent studies demonstrated that, in mice, activated IL-17-secreting CD4+ helper T cells (Th17 cells) mediate an autoimmune arthritis that clinically and immunologically resembles rheumatoid arthritis (RA). Human IL-17A shows 63%, 63%, and 72% amino acid sequence identity to rat IL-17A, mouse IL-17A, and a protein encoded by the ORF13 gene of herpesvirus Saimiri (HVS), respectively. |
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