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APC Polyclonal Antibody

Cat:E-AB-17831
Manual MSDS

Price: $ 399

Price: $ 240

Price: $ 143

Price: $ 73

Size:
200μL 120μL 60μL 20μL
Quantity:
  • Host: Rabbit
  • Reactivity: Human; Mouse; Rat
  • Applications: IHC
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Product Details
Verified Samples Verified Samples in IHC:Human liver cancer,Human thyroid cancer
Dilution

IHC 1:40-1:200

Western Blot Operation Guide
Clonality Polyclonal
Immunogen Synthetic peptide of human APC
Abbre APC
Synonyms Adenomatous Polyposis Coli;Adenomatous polyposis coli protein;Apc;APC;CC1;Deleted in polyposis 2.5;DP2;DP2.5;DP3;FAP;FPC;GS;Protein APC
Swissprot
Cellular Localization Cell junction>adherens junction. Cytoplasm>cytoskeleton. Cell projection>lamellipodium. Cell projection>ruffle membrane. Cytoplasm. Cell membrane. Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.
Concentration 1.1 mg/mL
Buffer PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
Purification Method Antigen affinity purification
Research Areas Cancer; Cell Biology; Cardiovascular; Epigenetics and Nuclear Signaling; Neuroscience; Stem Cells
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping Ice bag
background This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.