APC Polyclonal Antibody (E-AB-67493)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human lung, Human colon, Human breast cancer Verified Samples in IF: HT29, Mouse colon |
| Dilution | IHC 1:50-1:200, IF 1:50-1:200 |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC, IF |
| Clonality | Polyclonal |
| Immunogen | Recombinant fusion protein of human APC (NP_000029.2) |
| Abbre | APC |
| Synonyms | APC, BTPS2, DP2, DP2.5, DP3, GS, PPP1R46, PPP1R46抗体 |
| Swissprot | |
| Calculated MW | 311.6 kDa |
| Cellular Localization | Cell junction > adherens junction |
| Tissue Specificity | Expressed in a variety of tissues: brain, small intestine, colon, thymus, skeletal muscle, heart, prostate, lung, spleen, ovary, testis kidney, placenta, blood and liver (PubMed:21643010, PubMed:27217144). Isoform 1A: Very strongly expressed in brain but has relatively low expression levels in other tissues (PubMed:19527921, PubMed:21643010, PubMed:27217144). Isoform 1B: Predominant form in all tissues except for brain, including gastric mucosa and blood (PubMed:19527921, PubMed:21643010, PubMed:27217144). |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Cardiovascular, Epigenetics and Nuclear Signaling, Neuroscience, Stem Cells |
| Conjugation | Unconjugated |
| Storage | Store at -20℃ Valid for 12 months. Avoid freeze/thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. |
Note: Data for this module come from published literature that cites this product, displaying other products used together in the same research paper.
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