ASAH2 Polyclonal Antibody

Uniprot : Q9NR71
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14747

      Synonyms:Acylsphingosine deacylase 2,AI585898,ASAH2,ASAH2,BCDase,hCD,HNAC1,LCDase,MGC129777,mitochondrial ceramidase,N acylsphingosine amidohydrolase (non lysosomal ceramidase) 2,N acylsphingosine amidohydrolase 2,N CDase,N-acylsphingosine amidohydrolase 2,N-CDase,NCDase,Neutral ceramidase soluble form,Non lysosomal ceramidase,Non-lysosomal ceramidase

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Acylsphingosine deacylase 2,AI585898,ASAH2,ASAH2,BCDase,hCD,HNAC1,LCDase,MGC129777,mitochondrial ceramidase,N acylsphingosine amidohydrolase (non lysosomal ceramidase) 2,N acylsphingosine amidohydrolase 2,N CDase,N-acylsphingosine amidohydrolase 2,N-CDase,NCDase,Neutral ceramidase soluble form,Non lysosomal ceramidase,Non-lysosomal ceramidase
      Swissprot Q9NR71
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human ASAH2
      Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution WB 1:200-1:1000, IHC 1:25-1:100
      Concentration 0.7 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cell membrane. The neutral ceramidase soluble form is a secreted protein. According to PubMed:10781606, it is mitochondrial. However, they used a shorter form in its N-terminus, which may explain this localization which probably does not exist in vivo.
      Tissue specificity Primarily expressed in the intestine (PubMed:17334805). Ubiquitously expressed with higher levels in kidney, skeletal muscle and heart (PubMed:10781606). According to PubMed:17334805, ubiquitous expression attributed to ASAH2 may be actually that of the paralog ASAH2B.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background Ceramidases (EC 3.5.1.23), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger.

      Images

      Western Blot analysis of Lovo cell and Mouse heart tissue using ASAH2 Polyclonal Antibody at dilution of 1:270

      Immunohistochemistry of paraffin-embedded Human brain using ASAH2 Polyclonal Antibody at dilution of 1:50

      Immunohistochemistry of paraffin-embedded Human colon cancer using ASAH2 Polyclonal Antibody at dilution of 1:50

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