BRCA1 Polyclonal Antibody
Price: $ 399
Price: $ 240
Price: $ 143
Price: $ 73
Size:
200μL
120μL
60μL
20μL
Quantity:
- Host: Rabbit
- Reactivity: Human
- Applications: IHC
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Product Details
Verified Samples |
Verified Samples in IHC:Human liver cancer,Human cervical cancer |
Dilution |
WB 1:200-1:1000,IHC 1:50-200 Western Blot Operation Guide |
Clonality | Polyclonal |
Immunogen | Recombinant protein of human BRCA1 |
Abbre | BRCA1 |
Synonyms | BRCA 1;BRCA1;BRCA1 DNA repair associated;BRCA1/BRCA2 containing complex subunit 1;BRCA1/BRCA2-containing complex;subunit 1;BRCA1;BRCAI;BRCC 1;BRCC1;Breast and ovarian cancer susceptibility protein 1;Breast Cancer 1;Breast Cancer 1 Early Onset;Breast cancer type 1 susceptibility protein;BROVCA1;FANCS;IRIS;PNCA4;PPP1R53;Protein phosphatase 1 regulatory subunit 53;PSCP;RING finger protein 53;RNF53 |
Swissprot | |
Cellular Localization | Cytoplasm; Nucleus. Localizes at sites of DNA damage at double-strand breaks (DSBs) and recruitment to DNA damage sites is mediated by the BRCA1-A complex. |
Concentration | 0.3 mg/mL |
Buffer | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
Purification Method | Affinity purification |
Research Areas | Cancer; Cell Biology; Epigenetics and Nuclear Signaling |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | Biological ice pack at 4 ℃ |
background | This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. |
Experiment Operation Video
Protocols
• Western Blot Guide
• Immunohistochemistry Guide for Slide-mounted Paraffin Sections
• Immunofluorescence Guide
• Immunohistochemistry Troubleshooting Tips
• Western Blot Troubleshooting Tips
• Immunofluorescence Troubleshooting Tips
• Comparison of Protein Separation Linear Range
• ImmunoPrecipitation Protocol