CAD Polyclonal Antibody (E-AB-17759)
For research use only.
| Verified Samples |
Verified Samples in IHC: Human liver cancer, Human esophagus cancer |
| Dilution | IHC 1:40-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human CAD |
| Abbre | CAD |
| Synonyms | Aspartate carbamoyltransferase, Aspartate transcarbamylase, CAD protein, CAD trifunctional protein, CPSase ATCase DHOase, Carbamoyl phosphate synthetase 2, Carbamoyl-phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase, Dihydroorotase, Glutamine d |
| Swissprot | |
| Cellular Localization | Cytoplasmic and Nuclear. |
| Concentration | 0.7 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Antigen affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Other Clones
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Other Formats
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Unconjugated
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