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CD4 Monoclonal Antibody

Cat:E-AB-22098 Citations (2)
Manual MSDS
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Price: $ 399

Price: $ 240

Price: $ 143

Price: $ 73

Size:
200μL 120μL 60μL 20μL
Quantity:
  • Host: Mouse
  • Reactivity: Human;Mouse;Rat
  • Applications: IHC-p;IF
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For research use only. Order now, ship in 3 days

Product Details
Verified Samples Verified Samples in IHC:Human stomach,Mouse brain
Verified Samples in IF:Mouse colonic
Dilution

IHC 1:100-1:300, IF 1:50-200

Western Blot Operation Guide
Clonality Monoclonal
Immunogen Synthetic Peptide
Abbre CD4
Synonyms CD 4;CD4 (L3T4);CD4;CD4 antigen (p55);CD4 antigen;CD4 molecule;CD4 receptor;CD4+ Lymphocyte deficiency;included;CD4;CD4mut;L3T4;Leu3;Ly-4;Lymphocyte antigen CD4;MGC165891;OTTHUMP00000238897;p55;T cell antigen T4;T cell antigen T4/LEU3;T cell differentiation antigen L3T4;T cell OKT4 deficiency;included;T cell surface antigen T4/Leu 3;T cell surface antigen T4/Leu3;T cell surface glycoprotein CD4;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4;W3/25;W3/25 antigen
Swissprot
Cellular Localization Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Tissue Specificity Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells.
Concentration 1 mg/mL
Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
Purification Method Protein A purification
Research Areas Cancer; Immunology; Stem Cells
Clone No. Clone:9G1
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping Ice bag
background This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.