CD4 Monoclonal Antibody
- +1
Price: $ 399
Price: $ 240
Price: $ 143
Price: $ 73
Size:
200μL
120μL
60μL
20μL
Quantity:
- Host: Mouse
- Reactivity: Human;Mouse;Rat
- Applications: IHC-p;IF
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For research use only. Order now, ship in 3 days
Product Details
Verified Samples |
Verified Samples in IHC:Human stomach,Mouse brain Verified Samples in IF:Mouse colonic |
Dilution |
IHC 1:100-1:300, IF 1:50-200 Western Blot Operation Guide |
Clonality | Monoclonal |
Immunogen | Synthetic Peptide |
Abbre | CD4 |
Synonyms | CD 4;CD4 (L3T4);CD4;CD4 antigen (p55);CD4 antigen;CD4 molecule;CD4 receptor;CD4+ Lymphocyte deficiency;included;CD4;CD4mut;L3T4;Leu3;Ly-4;Lymphocyte antigen CD4;MGC165891;OTTHUMP00000238897;p55;T cell antigen T4;T cell antigen T4/LEU3;T cell differentiation antigen L3T4;T cell OKT4 deficiency;included;T cell surface antigen T4/Leu 3;T cell surface antigen T4/Leu3;T cell surface glycoprotein CD4;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4;W3/25;W3/25 antigen |
Swissprot | |
Cellular Localization | Cell membrane. Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum. |
Tissue Specificity | Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells such as macrophages, dendritic cells or NK cells. |
Concentration | 1 mg/mL |
Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
Purification Method | Protein A purification |
Research Areas | Cancer; Immunology; Stem Cells |
Clone No. | Clone:9G1 |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | Ice bag |
background | This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. |
Citations
-
Sexual dimorphism in Th17/Treg axis in lymph nodes draining inflamed joints in rats with collagen-induced arthritis
IF:6.306
Journal:BRAIN BEHAVIOR AND IMMUNITY
PMID:30476564
-
Small molecules targeting RORγt inhibit autoimmune disease by suppressing Th17 cell differentiation
IF:6.304
Journal:Cell Death & Disease
Experiment Operation Video
Protocols
• Western Blot Guide
• Immunohistochemistry Guide for Slide-mounted Paraffin Sections
• Immunofluorescence Guide
• Immunohistochemistry Troubleshooting Tips
• Western Blot Troubleshooting Tips
• Immunofluorescence Troubleshooting Tips
• Comparison of Protein Separation Linear Range
• ImmunoPrecipitation Protocol