CERK Polyclonal Antibody

Uniprot : Q8TCT0
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14742

      Synonyms:Acylsphingosine kinase,Ceramide kinase,Cerk,CERK1,dA59H18.2,dA59H18.3,hCERK,KIAA1646,Lipid kinase 4,Lipid kinase LK4,LK4

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms Acylsphingosine kinase,Ceramide kinase,Cerk,CERK1,dA59H18.2,dA59H18.3,hCERK,KIAA1646,Lipid kinase 4,Lipid kinase LK4,LK4
      Swissprot Q8TCT0
      Source Rabbit
      Reactivity Human,Mouse
      Immunogen Recombinant protein of human CERK
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:25-1:100
      Concentration 0.4 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytoplasm. Membrane.
      Tissue specificity High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide, 50% glycerol, PH7.3
      Background CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, apoptosis, phagocytosis, and inflammation. Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.

      Images

      Immunohistochemistry of paraffin-embedded Human tonsil tissue using CERK Polyclonal Antibody at dilution 1:50

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CERK Polyclonal Antibody at dilution 1:50

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