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CERS4 Polyclonal Antibody

Cat:E-AB-13375
Manual MSDS
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Price: $ 399

Price: $ 240

Price: $ 143

Price: $ 73

Size:
200μL 120μL 60μL 20μL
Quantity:
  • Host: Rabbit
  • Reactivity: Human
  • Applications: WB;IHC
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For research use only. Order now, ship in 3 days

Product Details
Verified Samples Verified Samples in WB:Human fetal liver,HT29,HUVEC,MCF-7,Human hepatocellsular carcinoma
Verified Samples in IHC:Human ovarian cancer,Human prostate cancer
Dilution

WB 1:500-1:2000, IHC 1:50-1:200

Western Blot Operation Guide
Clonality Polyclonal
Immunogen Synthetic peptide of human CERS4
Abbre CERS4
Synonyms ceramide synthase 4;CerS4;FLJ12089;LAG1 homolog ceramide synthase 4;LAG1 longevity assurance homolog 4;LAG1;S. cerevisiae;homolog of;4;LASS 4;LASS4;LASS4 LAG1 homolog ceramide synthase 4;LASS4;TRAM homolog 1;Trh 1;Trh1
Swissprot
Calculated MW 46kDa
Cellular Localization Nucleus membrane. Endoplasmic reticulum membrane.
Concentration 0.9 mg/mL
Buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method Affinity purification
Research Areas Cancer; Metabolism; Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping Biological ice pack at 4 ℃
background The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS4 is a 394 amino acid endoplasmic reticulum, multi-pass membrane protein. LASS4 increases the levels of long ceramides such as C22:0- and C24:0-ceramides. In cells deficient for CLN9, as observed in neuronal ceroid lipofuscinosis (NCL) or Batten disease, LASS4 can increase ceramide levels and partially correct growth and apoptosis.