COL1A1 Monoclonal Antibody

Uniprot : P02452
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    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
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    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience
    • monoclonal antibody-Elabscience

      Catalog number:E-AB-22152

      Synonyms:COL1A1,Alpha 1 type I collagen,Alpha-1 type I collagen,CO1A1,COL1A1,Collagen alpha-1(I) chain,Collagen type I alpha 1,Procollagen type I C terminal propeptide

      Size:
      • 20 μL
      • 60 μL
      • 120 μL
      • 200 μL
      Qty:
      - +
      Price: $69

      Host: Mouse

      Reactivity: H,M,R

      Applications: IHC-p

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms COL1A1,Alpha 1 type I collagen,Alpha-1 type I collagen,CO1A1,COL1A1,Collagen alpha-1(I) chain,Collagen type I alpha 1,Procollagen type I C terminal propeptide
      Swissprot P02452
      Source Mouse
      Reactivity Human,Mouse,Rat
      Immunogen Synthetic Peptide of Collagen I
      Application IHC-p(Detection kit: E-IR-R217)
      Recommended dilution IHC 1:50-300
      Concentration 1 mg/mL
      Clonality Monoclonal

      Properties

      Cellular localization Secreted>extracellular space>extracellular matrix.
      Tissue specificity Forms the fibrils of tendon, ligaments and bones. In bones the fibrils are mineralized with calcium hydroxyapatite.
      Clone No. Clone:3C3
      Isotype IgG
      Purification Protein A purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.4.
      Background COL1A1 (Collagen Type I Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL1A1 include Caffey Disease and Osteogenesis Imperfecta, Type I. Among its related pathways are Collagen chain trimerization and Transcription_Role of VDR in regulation of genes involved in osteoporosis. GO annotations related to this gene include identical protein binding and platelet-derived growth factor binding. An important paralog of this gene is COL2A1.This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

      Images

      monoclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Human lung cancer tissue using COL1A1 Monoclonal Antibody at dilution of 1:200.

      monoclonal antibody-Elabscience

      Immunohistochemistry of paraffin-embedded Rat kidney tissue using COL1A1 Monoclonal Antibody at dilution of 1:200.

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