DNMT3A Polyclonal Antibody

Uniprot : Q9Y6K1
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14623

      Synonyms:DNA (cytosine 5) methyltransferase 3 alpha,DNA (cytosine 5) methyltransferase 3A,DNA (cytosine-5)-methyltransferase 3A,DNA cytosine methyltransferase 3A2,DNA methyltransferase 3 alpha,DNA methyltransferase 3a,DNA methyltransferase HsaIIIA,DNA MTase HsaIIIA,DNM3A,DNMT 3a,DNMT,Dnmt3a,DNMT3A2,M.HsaIIIA,MCMT,OTTHUMP00000201149,TBRS

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms DNA (cytosine 5) methyltransferase 3 alpha,DNA (cytosine 5) methyltransferase 3A,DNA (cytosine-5)-methyltransferase 3A,DNA cytosine methyltransferase 3A2,DNA methyltransferase 3 alpha,DNA methyltransferase 3a,DNA methyltransferase HsaIIIA,DNA MTase HsaIIIA,DNM3A,DNMT 3a,DNMT,Dnmt3a,DNMT3A2,M.HsaIIIA,MCMT,OTTHUMP00000201149,TBRS
      Swissprot Q9Y6K1
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human DNMT3A
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:50-1:200
      Concentration 0.4 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus. Cytoplasm. Accumulates in the major satellite repeats at pericentric heterochromatin.
      Tissue specificity Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

      Images

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using DNMT3A Polyclonal Antibody at dilution 1:50

      Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using DNMT3A Polyclonal Antibody at dilution 1:50

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