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DOK4 Polyclonal Antibody

Cat:E-AB-14690
Manual MSDS

Price: $ 399

Price: $ 240

Price: $ 143

Price: $ 73

Size:
200μL 120μL 60μL 20μL
Quantity:
  • Host: Rabbit
  • Reactivity: Human;Mouse
  • Applications: IHC
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Product Details
Verified Samples Verified Samples in IHC:Human gastric cancer,Human liver cancer
Dilution

IHC 1:50-1:200

Western Blot Operation Guide
Clonality Polyclonal
Immunogen Recombinant protein of human DOK4
Abbre DOK4
Synonyms docking protein 4;Downstream of tyrosine kinase 4;FLJ10488;insulin receptor substrate 5;IRS5
Swissprot
Cellular Localization Cytosol
Concentration 0.6 mg/mL
Buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method Affinity purification
Research Areas Cancer; Neuroscience; Signal Transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping Biological ice pack at 4 ℃
background Docking protein 4is aproteinthat in humans is encoded by theDOK4gene. Dok-4 is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.