EID1 Polyclonal Antibody (E-AB-14978)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Human liver cancer, Human esophagus cancer |
| Dilution | IHC 1:50-1:200 |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Reactivity | Human |
| Applications | IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human EID1 |
| Abbre | EID1 |
| Synonyms | 21 kDa pRb associated protein, 21 kDa pRb-associated protein, C15orf3, CBP, Chromosome 15 open reading frame 3, CREBBP/EP300 inhibitor 1, CREBBP/EP300 inhibitory protein 1, CRI 1, CRI1, E1A like inhibitor of differentiation, E1A-like inhibitor of differentiation 1, EID 1, EID-1, EID1, EP300 interacting inhibitor of differentiation 1, EP300-interacting inhibitor of differentiation 1, IRO45620, MGC138883, MGC138884, NB4 apoptosis related protein, PNAS 22, PNAS22, PTD014, Rb and p300 binding protein EID 1, Rb and p300 binding protein EID1, RBP21, Retinoblastoma protein associated protein抗体 |
| Swissprot | |
| Cellular Localization | Nucleus. Cytoplasm. May shuttle between nucleus and cytoplasm. |
| Concentration | 0.6 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator. |
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