(KO Validated) EIF4E Polyclonal Antibody (E-AB-60650)
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For research use only.
| Verified Samples |
Verified Samples in IHC: Human lung cancer, Human stomach Verified Samples in IF: U2OS |
| Dilution | IHC 1:50-1:100, IF 1:50-1:200 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| Clonality | Polyclonal |
| Immunogen | A synthetic peptide of human EIF4E (NP_001959.1). |
| Abbre | EIF4E |
| Synonyms | AUTS19, CBP, EIF4E, EIF4E1, EIF4EL1, EIF4F, eIF-4E |
| Swissprot | |
| Cellular Localization | Cytosol, Extracellular region or secreted, extracellular exosome, Other locations: chromatoid body, cytoplasm, cytoplasmic ribonucleoprotein granule, cytoplasmic stress granule, eukaryotic translation initiation factor 4F complex, mRNA cap binding complex, P-body, perinuclear region of cytoplasm, RISC complex. |
| Concentration | 1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. |
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