EPS15L1 Polyclonal Antibody (E-AB-10879)
For research use only.
| Verified Samples |
Verified Samples in WB: Hela, PC-3, 231, 293T Verified Samples in IHC: Human thyroid cancer, Human colon cancer |
| Dilution | WB 1:500-1:2000, IHC 1:25-1:100 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human EPS15L1 |
| Abbre | EPS15L1 |
| Synonyms | EP15R, Epidermal growth factor receptor substrate 15 like 1, Epidermal growth factor receptor substrate 15-like 1, Eps15 related protein, Eps15-rela, epidermal growth factor receptor pathway substrate 15- ike 1, epidermal growth factor receptor substrate EPS15R |
| Swissprot | |
| Calculated MW | 94 kDa |
| Cellular Localization | Cell membrane. Nucleus. Membrane>coated pit. Localized to plasma membrane coated pits. |
| Concentration | 0.1 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Epidermal growth factor receptor substrate 15-like 1is aproteinthat in humans is encoded by the EPS15L1 gene. Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2) By similarity. Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2. |
Other Clones
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Other Formats
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Unconjugated
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