FADD Polyclonal Antibody

Uniprot : Q13158
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14078

      Synonyms:FADD,FADD protein,FADD,Fas (TNFRSF6) associated via death domain,Fas associated via death domain,Fas associating death domain containing protein,Fas associating protein,Fas associating protein with death domain,Fas TNFRSF6 associated via death domain,FAS-associated death domain protein,FAS-associating death domain-containing protein,GIG 3,GIG3,Growth inhibiting gene 3 protein,Growth-inhibiting gene 3 protein,H sapiens mRNA for mediator of receptor induced toxicity,Mediator of receptor induced toxicity,MGC8528,MORT 1,MORT1,Protein FADD

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H

      Applications: IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms FADD,FADD protein,FADD,Fas (TNFRSF6) associated via death domain,Fas associated via death domain,Fas associating death domain containing protein,Fas associating protein,Fas associating protein with death domain,Fas TNFRSF6 associated via death domain,FAS-associated death domain protein,FAS-associating death domain-containing protein,GIG 3,GIG3,Growth inhibiting gene 3 protein,Growth-inhibiting gene 3 protein,H sapiens mRNA for mediator of receptor induced toxicity,Mediator of receptor induced toxicity,MGC8528,MORT 1,MORT1,Protein FADD
      Swissprot Q13158
      Source Rabbit
      Reactivity Human
      Immunogen Recombinant protein of human FADD
      Application IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution IHC 1:50-1:150
      Concentration 0.6 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Cytosol,ripoptosome,Nucleus,Plasma Membrane,CD95 death-inducing signaling complex,death-inducing signaling complex,plasma membrane,Other locations:cell body,cytoplasm,membrane raft,neuron projection
      Tissue specificity Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

      Images

      Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using FADD Polyclonal Antibody at dilution 1:50

      Immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using FADD Polyclonal Antibody at dilution 1:50

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