FITC Anti-Human CD49d Antibody[9F10] (E-AB-F1144C)
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For research use only.
| Isotype | Mouse IgG1, κ |
| Host | Mouse |
| Reactivity | Human |
| Applications | FCM |
| Clonality | Monoclonal |
| Isotype Control | FITC Mouse IgG1, κ Isotype Control[MOPC-21] |
| Abbre | CD49d |
| Synonyms | CD49 antigen-like family member D, CD49d, ITGA4, Integrin alpha-4, Integrin alpha-IV, VLA-4 subunit alpha |
| Swissprot | |
| Cellular Localization | Membrane |
| Concentration | 5 μL/Test |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
| Research Areas | Cell Adhesion, Cell Biology, Immunology, Innate Immunity |
| Clone No. | 9F10 |
| Conjugation | FITC |
| Conjugation Information | FITC is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 530 nm (e.g., a 525/40 nm bandpass filter). |
| Spectrum |
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| Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
| Shipping | Ice bag |
| background | CD49d is a 150 kD α integrin chain known as α4 integrin or VLA-4 α chain. It forms a heterodimer with either integrin β1 (α4β1, VLA-4) or β7 (α4β7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. α4β7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells. |
| Cat.No. | Product Name | Clone No. |
|---|---|---|
| E-AB-F1040C | FITC Anti-Human CD49d Antibody[BU49] | BU49 |
| E-AB-F1359C | FITC Anti-Human CD49d Antibody[HP1/2] | HP1/2 |
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