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For research use only.

Verified Samples Verified Samples in IHC: Human tonsil
Dilution IHC 1:30-1:150
Isotype Rabbit IgG
Host Rabbit
Reactivity Human,  Mouse
Applications IHC
Clonality Polyclonal
Immunogen Synthetic peptide of human GPSM2
Abbre GPSM2
Synonyms DFNB82,  G protein signalling modulator 2,  G protein signalling modulator 2 (AGS3 like C. elegans),  G-protein-signaling modulator 2,  GPSM2,  HGNC:29501,  LGN,  LGN protein,  Mosaic protein LGN,  Pins
Swissprot
Cellular Localization Cytoplasm. Cytoplasm>cell cortex. Localizes in the cytoplasm in the interphase and at cell periphery in the metaphase.
Concentration 1.92 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Antigen affinity purification
Research Areas Cancer,  Cell Biology,  Signal transduction
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses.The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange.This protein may play a role in neuroblast division and in the development of normal hearing.Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82).Alternative splicing results in multiple transcript variants.
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