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For research use only.

Verified Samples Verified Samples in IF: U2OS
Dilution IF 1:10-1:100
Isotype IgG
Host Rabbit
Reactivity Human,  Mouse,  Rat
Applications IF
Clonality Polyclonal
Immunogen Recombinant fusion protein of human Heparanase 1 (NP_001092010.1).
Abbre Heparanase 1
Synonyms HPA,  HPA1,  HPR1,  HPSE,  HPSE1,  HSE1,  heparanase
Swissprot
Cellular Localization Lysosome membrane. Secreted. Secreted, internalised and transferred to late endosomes/lysosomes as a proheparanase. In lysosomes, it is processed into the active form, the heparanase. The uptake or internalisation of proheparanase is mediated by HSPGs. Heparin appears to be a competitor and retain proheparanase in the extracellular medium.
Concentration 1 mg/mL
Buffer Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Purification Method Affinity purification
Research Areas Cancer,  Signal Transduction,  Tags and Cell Markers
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
background Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular matrix. In addition, this cleavage can release bioactive molecules from the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene.
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Unconjugated

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