Human AR Antibody Pair Set (E-KAB-0676)
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For research use only.
| Background |
Amphiregulin was initially identified in the conditioned medium of human mammary gland MCF-7 cells treated with TPA. The mouse gene was cloned from the androgen-dependent SC2G cell line derived from Shionogi mouse mammary carcinoma SC115. It belongs to the EGF family of proteins that includes EGF,TGF-α,heparin-binding EGF like-growth factor (HB-EGF),epigen,epiregulin,and betacellulin. Mouse amphiregulin is derived from a 248 amino acid transmembrane precursor and it has 66% identity to the human protein. All the EGF family members are synthesized as type I membrane protein precursors,which can undergo proteolytic cleavage at the plasma membrane to release a mature soluble ectodomain. ADAM17 (TACE) has an important role in ectodomain shedding of amphiregulin,TNF-α,and HB-EGF.
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| Synonyms |
AREG, CRDGF, SDGF
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human AR in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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| Introduction |
This ELISA kit applies to the in vitro quantitative determination of Human AR concentrations in serum, plasma and other biological fluids.
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