Human CD30 Antibody Pair Set (E-KAB-0417)
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For research use only.
| Background |
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor ( TNF ) ligand family. This cytokine is a ligand for TNFRSF8/CD30 , which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines , while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene.
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| Synonyms |
CD30, D1S166E, Ki-1, TNF receptor superfamily member 8, TNFRSF8, Tumor necrosis factor receptor superfamily member 8
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human CD30 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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