Human FGF1 Antibody Pair Set (E-KAB-0707)

FGF-1,one of the most studied members of the fibroblast growth factor family,is a powerful mitogen exhibiting strong action on many different cell types.   FGF-1 activity can be mediated not only by autocrine/paracrine pathways but also by an intracrine pathway.   FGF-1 lacks a secretion signal peptide and is exported through a non-classical pathway.   Endogenous FGF-1 is found in the nucleus of most cell types.   Nuclear localization is required for FGF-1 mitogenic activity.   FGF-1 promotes tumor development by promoting cancer cell proliferation and survival.   Increased FGF-1 expression in early stages of many different cancers has been reported.  Under oxidative stress,astrocytes can also release FGF-1 which stimulates ApoE/HDL generation in an autocrine manner for protection of the brain against oxidative stress.   Involvement of FGF-1 in inflammation,cardioprotection,wound healing,adipocyte remodeling,and restenosis is also reported.

FGF-1, ECGF, ECGF-beta, A-FGF, FGFA, ECGFA, ECGFB, FGF-Alpha, HBGF1, HBGF-1, ECGFB, GLIO703, Heparin-binding growth factor 1

Human

Detects Human FGF1 in ELISAs

ELISA

-20℃

12 months

This ELISA kit applies to the in vitro quantitative determination of Human FGF1 concentrations in serum, plasma and other biological fluids.