Human PCX Antibody Pair Set (E-KAB-0460)
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For research use only.
| Background |
Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule , enhancing the adherence of cells to immobilized ligands , increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events , leading to increased activities of the MAPK and PI3K pathways in cancer cells.
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| Synonyms |
GCTM-2 antigen, Gp2, PC, PCLP, PCLP-1, PCLP1, PODXL, Podocalyxin-like protein 1
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| Swissprot | |
| Reactivity |
Human
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| Specificity |
Detects Human PCX in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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