IDH2 Polyclonal Antibody (E-AB-15121)
For research use only.
| Verified Samples |
Verified Samples in WB: 293T, Jurkat, Human fetal muscle Verified Samples in IHC: Human cervical cancer, Human colon cancer |
| Dilution | WB 1:500-1:2000, IHC 1:100-1:300 |
| Isotype | IgG |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human IDH2 |
| Abbre | IDH2 |
| Synonyms | D2HGA2, ICD-M, IDH, IDH2, IDHM, IDHP, IDP, IDPM, Isocitrate dehydrogenase 2 (NADP+), Isocitrate dehydrogenase [NADP], NADP(+)-specific ICDH, Oxalosuccinate decarboxylase, mNADP-IDH, mitochondrial |
| Swissprot | |
| Calculated MW | 51 kDa |
| Cellular Localization | Mitochondrion. |
| Concentration | 0.4 mg/mL |
| Buffer | Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol. |
| Purification Method | Affinity purification |
| Research Areas | Cancer, Metabolism, Signal Transduction |
| Conjugation | Unconjugated |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Shipping | The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended. |
| background | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. |
Other Clones
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Other Formats
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Unconjugated
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