KCNIP3 Polyclonal Antibody
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Size:
200μL
120μL
60μL
20μL
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- Host: Rabbit
- Reactivity: Human; Mouse; Rat
- Applications: IHC
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Product Details
Verified Samples |
Verified Samples in IHC:Human brain |
Dilution |
IHC 1:50-1:100 Western Blot Operation Guide |
Clonality | Polyclonal |
Immunogen | Fusion protein of human KCNIP3 |
Abbre | KCNIP3 |
Synonyms | 4933407H12Rik;A type potassium channel modulatory protein 3;A-type potassium channel modulatory protein 3;AI413860;Calsenilin;CSEN;CSEN;DRE antagonist modulator;DRE-antagonist modulator;DREAM;EF hand transcription factor;KCHIP 3;KChIP3;KCNIP 3;Kcnip3;Kv channel interacting protein 3;Kv channel-interacting protein 3;MGC18289;Potassium channel interacting protein 3;R74849 |
Swissprot | |
Cellular Localization | Cytoplasm. Cell membrane. Endoplasmic reticulum. Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. |
Concentration | 1.62 mg/mL |
Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
Purification Method | Antigen affinity purification |
Research Areas | Cancer; Cardiovascular; Neuroscience; Signal Transduction |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | Ice bag |
background | This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. KCNIP3 (Potassium Voltage-Gated Channel Interacting Protein 3) is a Protein Coding gene. Diseases associated with KCNIP3 include Alzheimer Disease. Among its related pathways are Cardiac conduction and Development Ligand-independent activation of ESR1 and ESR2. GO annotations related to this gene include calcium ion binding and transcription corepressor activity. An important paralog of this gene is KCNIP4. |
Experiment Operation Video
Protocols
• Western Blot Guide
• Immunohistochemistry Guide for Slide-mounted Paraffin Sections
• Immunofluorescence Guide
• Immunohistochemistry Troubleshooting Tips
• Western Blot Troubleshooting Tips
• Immunofluorescence Troubleshooting Tips
• Comparison of Protein Separation Linear Range
• ImmunoPrecipitation Protocol