KDM2A Polyclonal Antibody
Price: $ 399
Price: $ 240
Price: $ 143
Price: $ 73
Size:
200μL
120μL
60μL
20μL
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- Host: Rabbit
- Reactivity: Human; Mouse
- Applications: IHC
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Product Details
Verified Samples |
Verified Samples in IHC:Human lung cancer,Human esophagus cancer |
Dilution |
IHC 1:50-1:300 Western Blot Operation Guide |
Clonality | Polyclonal |
Immunogen | Synthetic peptide of human KDM2A |
Abbre | KDM2A |
Synonyms | [Histone-H3]-lysine-36 demethylase 1A;CXXC-type zinc finger protein 8;CXXC8;F box / LRR repeat protein 11;F box and leucine rich repeat protein 11;F box protein FBL7;F-box and leucine-rich repeat protein 11;F-box protein FBL7;F-box protein Lilina;F-box/LRR-repeat protein 11;FBL11;FBL7;FBXL11;JHDM1A;JmjC domain-containing histone demethylation protein 1A;Jumonji C domain containing histone demethylase 1A ;kdm2a;KDM2A;LILINA;Lysine (K) specific demethylase 2A;Lysine-specific demethylase 2A |
Swissprot | |
Cellular Localization | Nucleus>nucleoplasm. Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where it's presence results in chromatin depleted in H3K36me2. |
Concentration | 1.62 mg/mL |
Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
Purification Method | Antigen affinity purification |
Research Areas | Cancer; Epigenetics and Nuclear Signaling |
Conjugation | Unconjugated |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Shipping | Ice bag |
background | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. |
Experiment Operation Video
Protocols
• Western Blot Guide
• Immunohistochemistry Guide for Slide-mounted Paraffin Sections
• Immunofluorescence Guide
• Immunohistochemistry Troubleshooting Tips
• Western Blot Troubleshooting Tips
• Immunofluorescence Troubleshooting Tips
• Comparison of Protein Separation Linear Range
• ImmunoPrecipitation Protocol