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KDM4D Polyclonal Antibody

Cat:E-AB-11341
Manual MSDS

Price: $ 399

Price: $ 240

Price: $ 143

Price: $ 73

Size:
200μL 120μL 60μL 20μL
Quantity:
  • Host: Rabbit
  • Reactivity: Human;Mouse;Rat
  • Applications: IHC
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Product Details
Verified Samples Verified Samples in IHC:Human prostate cancer
Dilution

IHC 1:25-1:100

Western Blot Operation Guide
Clonality Polyclonal
Immunogen Recombinant protein of human KDM4D
Abbre KDM4D
Synonyms JHD3D;JHDM3D;JmjC domain-containing histone demethylation protein 3D;Jumonji domain-containing protein 2D;Kdm4d;KDM4D;Lysine-specific demethylase 4D
Swissprot
Cellular Localization Nucleus.
Concentration 0.3 mg/mL
Buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method Affinity purification
Research Areas Cancer; Epigenetics and Nuclear Signaling
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping Biological ice pack at 4 ℃
background JMJD2D (Jumonji domain-containing protein 2D), also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thought to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D may be involved in carcinogenesis.