MCM6 Polyclonal Antibody

Uniprot : Q14566
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
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    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience
    • polyclonal antibody-Elabscience

      Catalog number:E-AB-14210

      Synonyms:DNA replication licensing factor MCM6,MCG40308,Mcm6,MCM6 minichromosome maintenance deficient 6 (MIS5 homolog,S. pombe),MCM6 minichromosome maintenance deficient 6,MCM6,Minichromosome maintenance complex component 6,Minichromosome maintenance deficient (mis5 S. pombe) 6,Minichromosome maintenance deficient 6 homolog,Minichromosome maintenance protein 6,Mis5,MIS5 homolog,p105MCM

      Size:
      • 20μL
      • 60μL
      • 120μL
      • 200μL
      Qty:
      - +
      Price: $69

      Host: Rabbit

      Reactivity: H,M,R

      Applications: WB,IHC,ELISA

      Lead Time: 7~10 daysWelcome to order from local distributors.

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      Overview

      Synonyms DNA replication licensing factor MCM6,MCG40308,Mcm6,MCM6 minichromosome maintenance deficient 6 (MIS5 homolog,S. pombe),MCM6 minichromosome maintenance deficient 6,MCM6,Minichromosome maintenance complex component 6,Minichromosome maintenance deficient (mis5 S. pombe) 6,Minichromosome maintenance deficient 6 homolog,Minichromosome maintenance protein 6,Mis5,MIS5 homolog,p105MCM
      Swissprot Q14566
      Source Rabbit
      Reactivity Human,Mouse,Rat
      Immunogen Recombinant protein of human MCM6
      Application WB(Detection kit: E-IR-R304),IHC(Detection kit: E-IR-R213),ELISA
      Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300
      Concentration 0.8 mg/mL
      Clonality Polyclonal

      Properties

      Cellular localization Nucleus. Binds to chromatin during G1 and detach from it during S phase.
      Isotype IgG
      Purification Affinity purification
      Conjugation Unconjugated
      Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
      Storage buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
      Background The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. 

      Images

      Western Blot analysis of 293T, A549, Raji, K562 and NIH/3T3 cell using MCM6 Polyclonal Antibody at dilution of 1:433.3

      Immunohistochemistry of paraffin-embedded Human esophagus cancer using MCM6 Polyclonal Antibody at dilution of 1:60

      Immunohistochemistry of paraffin-embedded Human colon cancer using MCM6 Polyclonal Antibody at dilution of 1:60

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