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MDC1 Polyclonal Antibody

Cat:E-AB-12802
Manual MSDS

Price: $ 399

Price: $ 240

Price: $ 143

Price: $ 73

Size:
200μL 120μL 60μL 20μL
Quantity:
  • Host: Rabbit
  • Reactivity: Human
  • Applications: IHC
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Product Details
Verified Samples Verified Samples in IHC:Human brain
Dilution

IHC 1:100-1:300

Western Blot Operation Guide
Clonality Polyclonal
Immunogen Synthetic peptide of human MDC1
Abbre MDC1
Synonyms Homologue to Drosophila photoreceptor protein calphotin;MDC 1;Mdc1;MDC1;Mediation of DNA damage checkpoint 1;Mediator of DNA damage checkpoint 1;Mediator of DNA damage checkpoint protein 1;NFBD 1;NFBD1;Nuclear factor with BRCT domains 1;Nuclear Factor with BRCT Domains Protein 1
Swissprot
Cellular Localization Nucleus. Associated with chromatin. Relocalizes to discrete nuclear foci following DNA damage, this requires 'Ser-139' phosphorylation of H2AFX. Colocalizes with APTX at sites of DNA double-strand breaks.
Concentration 1.2 mg/mL
Buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification Method Affinity purification
Research Areas Cancer; Epigenetics and Nuclear Signaling
Conjugation Unconjugated
Storage Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Shipping Biological ice pack at 4 ℃
background The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.