Mouse ALPL Antibody Pair Set (E-KAB-0702)
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For research use only.
| Background |
Alkaline phosphatases function physiologically as homodimers. They catalyze the hydrolysis of phosphomonoesters and release inorganic phosphate. In humans,four isoenzymes have been described: a tissue-nonspecific (TNAP) and three tissue-specific placental (PLAP),intestinal (IAP),and germ cell (GCAP). TNAP is a cell membrane-bound ecto-enzyme that releases inorganic phosphate from phosphate-enriched substrates. Also,ALPL induces the hydrolysis of extracellular inorganic pyrophosphate (PPi) which is a potent endogenous inhibitor of calcification both in vivo and in vitro. Increased activity of the enzyme alkaline phosphatase is associated with lower levels of PPi and vascular calcification present in patients with chronic kidney disease.
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| Synonyms |
ALPL, AP-TNAP, APTNAP, HOPS, TNAP, TNSALP, alkaline phosphatase, liver/bone/kidney, TNALP
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| Swissprot | |
| Reactivity |
Mouse
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| Specificity |
Detects Mouse ALPL in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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| Introduction |
This ELISA kit applies to the in vitro quantitative determination of Mouse ALPL concentrations in serum, plasma and other biological fluids.
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