Mouse IL-18 Antibody Pair Set (E-KAB-0568)
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For research use only.
| Background |
Interleukin-18 ( L-18 ) is a cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. IL-18 works by binding to the interleukin-18 receptor , and together with IL-12 it induces cell-mediated immunity following infection with microbial products like lipopolysaccharide ( LPS ) . After stimulation with IL-18 , natural killer ( NK ) cells and certain T cells release another important cytokine called interferon-γ ( IFN-γ ) or type II interferon that plays an important role in activating the macrophages or other cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production , and enhance IgG2a production in B cells. IL-18 binding protein ( IL18BP ) can specifically interact with this cytokine , and thus negatively regulate its biological activity.
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| Synonyms |
IL18, IGIF, IL-1g, IL-1F4, Interferon-gamma-inducing factor
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| Swissprot | |
| Reactivity |
Mouse
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| Specificity |
Detects Mouse IL-18 in ELISAs
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| Applications |
ELISA
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| Storage |
-20℃
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| Expiration date |
12 months
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